Western blot analysis of DLX4 in MDA-MB-231 cell lysates using DLX4 polyclonal antibody (Cat # PAB12448).
Western blot analysis of DLX4 using DLX4 polyclonal antibody (Cat # PAB12448). Lane 1 : DLX4-specific band (36 KDa) from 10ug of cell extract with antibody diluted 1 : 5 000. Lane 2 : DLX4-specific band after immunoprecipitation of 850 ug of cell extract using DLX4 polyclonal antibody (Cat # PAB12448) at 1 : 1000. Lane 3 : Negative control for IP in lane 2; cell extract incubated with 50 uL of Protein A/G beads.
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq
beta protein 1,distal-less homeo box 7,distal-less homeo box 9