ERN1 (phospho S724) polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of phosphorylated ERN1 in min6 cells, treated with glucose for 3 hours using ERN1 (phospho S724) polyclonal antibody (Cat # PAB12435).
Western Blot (Transfected lysate)
Western blot analysis of phosphorylated ERN1 using ERN1 (phospho S724) polyclonal antibody (Cat # PAB12435). Lane 1 : COS-7 untransfected.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ERN1.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S724 of human ERN1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of phosphorylated ERN1 in min6 cells, treated with glucose for 3 hours using ERN1 (phospho S724) polyclonal antibody (Cat # PAB12435).Western Blot (Transfected lysate)
Western blot analysis of phosphorylated ERN1 using ERN1 (phospho S724) polyclonal antibody (Cat # PAB12435). Lane 1 : COS-7 untransfected. -
Gene Info — ERN1
Entrez GeneID
2081Protein Accession#
O75460Gene Name
ERN1
Gene Alias
FLJ30999, IRE1, IRE1P, MGC163277, MGC163279
Gene Description
endoplasmic reticulum to nucleus signaling 1
Omim ID
604033Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq
Other Designations
ER to nucleus signalling 1|endoplasmic reticulum to nucleus signalling 1|inositol-requiring 1|protein kinase/endoribonuclease
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Interactome
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Disease
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Publication Reference
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Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.
Sugeno N, Takeda A, Hasegawa T, Kobayashi M, Kikuchi A, Mori F, Wakabayashi K, Itoyama Y.
The Journal of Biological Chemistry 2008 Aug; 283(34):23179.
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AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response.
Luo D, He Y, Zhang H, Yu L, Chen H, Xu Z, Tang S, Urano F, Min W.
The Journal of Biological Chemistry 2008 May; 283(18):11905.
Application：WB-Ce, Human, HUVECs.
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Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.
Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, Bortell R, Rossini AA, Urano F.
Cell Metabolism 2006 Sep; 4(3):245.
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Identification and characterization of JMJD2 family genes in silico.
Katoh M, Katoh M.
International Journal of Oncology 2004 Jun; 24(6):1623.
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Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.
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