EZH2 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of EZH2 in Jurkat whole cell lysate using EZH2 polyclonal antibody (Cat # PAB12430).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of EZH2.
Immunogen
A synthetic peptide corresponding to amino acids 300-400 of human EZH2.
Host
Rabbit
Reactivity
Human, Mouse, Primates
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of EZH2 in Jurkat whole cell lysate using EZH2 polyclonal antibody (Cat # PAB12430). -
Gene Info — EZH2
Entrez GeneID
2146Protein Accession#
Q15910Gene Name
EZH2
Gene Alias
ENX-1, EZH1, KMT6, MGC9169
Gene Description
enhancer of zeste homolog 2 (Drosophila)
Omim ID
601573Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
enhancer of zeste 2
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Interactome
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Disease
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Publication Reference
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Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC.
Science 2005 Oct; 310(5746):306.
Application：IP, WB, Human, MDA-MB-453, T-47D cells.
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Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.
Su IH, Basavaraj A, Krutchinsky AN, Hobert O, Ullrich A, Chait BT, Tarakhovsky A.
Nature Immunology 2003 Feb; 4(2):124.
Application：WB-Ce, Mouse, B cells.
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Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.
Hobert O, Jallal B, Ullrich A.
Molecular and Cellular Biology 1996 Jun; 16(6):3066.
Application：IP, Human, HEK 293 cells, HEL cells, Jurkat cells.
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Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
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