FANCA polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FANCA.
Immunogen
A synthetic peptide corresponding to amino acids 1200-1300 of human FANCA.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In antiserum
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Transfected lysate)
Western blot analysis of FANCA in transfected COS-1 cell lysate using FANCA polyclonal antibody (Cat # PAB12429). -
Gene Info — FANCA
Entrez GeneID
2175Protein Accession#
O15360Gene Name
FANCA
Gene Alias
FA, FA-H, FA1, FAA, FACA, FAH, FANCH, MGC75158
Gene Description
Fanconi anemia, complementation group A
Gene Ontology
HyperlinkGene Summary
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq
Other Designations
Fanconi anemia, complementation group H|Fanconi anemia, type 1
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Interactome
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Disease
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Publication Reference
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Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins.
Park SJ, Ciccone SL, Beck BD, Hwang B, Freie B, Clapp DW, Lee SH.
The Journal of Biological Chemistry 2004 May; 279(29):30053.
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Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins.
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