FOXP3 polyclonal antibody
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More Files
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Western Blot
Western blot analysis of murine FOXP3 using FOXP3 polyclonal antibody (Cat # PAB12427). Lane 1 : Human CD4+CD25+ PBL, lane 2 : HEK293T transfected with human Foxp3 cDNA, lane 3 : 293/mouse foxp3, lane 4 : 293/empty vector.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FOXP3.
Immunogen
A synthetic peptide corresponding to amino acids 1-50 of human FOXP3.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to FOXP3.
Form
Liquid
Recommend Usage
Western Blot (1:1000-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.09% sodium azide
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of murine FOXP3 using FOXP3 polyclonal antibody (Cat # PAB12427). Lane 1 : Human CD4+CD25+ PBL, lane 2 : HEK293T transfected with human Foxp3 cDNA, lane 3 : 293/mouse foxp3, lane 4 : 293/empty vector. -
Gene Info — FOXP3
Entrez GeneID
50943Protein Accession#
Q9BZS1Gene Name
FOXP3
Gene Alias
AIID, DIETER, IPEX, JM2, MGC141961, MGC141963, PIDX, XPID
Gene Description
forkhead box P3
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000025832|immune dysregulation, polyendocrinopathy, enteropathy, X-linked|immunodeficiency, polyendocrinopathy, enteropathy, X-linked|scurfin
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Interactome
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Disease
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Publication Reference
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Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
Lim HW, Hillsamer P, Banham AH, Kim CH.
The Journal of Immunology 2005 Oct; 175(7):4180.
Application：IF, IHC, Human, Tonsil.
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FOXP3 acts as a rheostat of the immune response.
Ochs HD, Ziegler SF, Torgerson TR.
Immunological Reviews 2005 Feb; 203:156.
Application：WB, Mouse, Mouse T cells.
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Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment.
Polanczyk MJ, Carson BD, Subramanian S, Afentoulis M, Vandenbark AA, Ziegler SF, Offner H.
Journal of Immunology 2004 Aug; 173(4):2227.
Application：WB-Tr, Human, HEK 293T cells.
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Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
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