HIF1A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant HIF1A.
Immunogen
Recombinant protein corresponding to amino acids 432-528 of human HIF1A.
Host
Rabbit
Reactivity
Bovine, Human, Mouse, Pig
Specificity
This antibody is specific to HIF-1 alpha.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Detection of HIF1A in Cobalt Chloride treated/untreated COS-7 nuclear extracts using HIF1A polyclonal antibody (Cat # PAB12419).Immunohistochemistry
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Gene Info — HIF1A
Entrez GeneID
3091Protein Accession#
Q16665Gene Name
HIF1A
Gene Alias
HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
Gene Description
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Omim ID
603348Gene Ontology
HyperlinkGene Summary
Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq
Other Designations
ARNT interacting protein|hypoxia-inducible factor 1, alpha subunit|hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)|member of PAS superfamily 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Oxygen-regulated gene expression in bovine blastocysts.
Harvey AJ, Kind KL, Pantaleon M, Armstrong DT, Thompson JG.
Biology of Reproduction 2004 Oct; 71(4):1108.
Application:IF, Bovine, Bovine blastocysts.
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Hyperoxia prevents carrageenan-induced enlargement of functional residual lung capacity in rats.
Fisarkova B, Vizek M.
Physiological Research 2003 Jan; 52(6):763.
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Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain.
Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR.
Annals of Neurology 2000 Sep; 48(3):285.
Application:IHC-Fr, WB-Ti, Rat, Rat cerebral cortex.
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Oxygen-regulated gene expression in bovine blastocysts.
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