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INSIG1 polyclonal antibody

  • Catalog # : PAB12411
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of INSIG1.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 1-100 of human INSIG1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific to Insig1 but not Insig2.
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (30% glycerol, 0.09% sodium azide)
  • Storage Instruction:
  • Store at -20°C or -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of INSIG1 in HepG2 lyaste using INSIG1 polyclonal antibody (Cat # PAB12411).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 3638
  • Gene Name:
  • INSIG1
  • Gene Alias:
  • CL-6,MGC1405
  • Gene Description:
  • insulin induced gene 1
  • Gene Summary:
  • Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
  • Other Designations:
  • INSIG-1 membrane protein
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