KIF2A polyclonal antibody
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More Files
- More Functions
Immunofluorescence
Staining of KIF2A on HeLa cells fixed in 3.5% paraformaldehyde using KIF2A polyclonal antibody (Cat # PAB12407) (1 : 5,000). Centrosome staining during interphase and spindle pole staining during mitosis.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant KIF2A.
Immunogen
Recombinant protein corresponding to N-terminus of human KIF2A.
Host
Rabbit
Reactivity
Human, Mammals, Mouse, Rat
Specificity
This antibody is specific to Kif2a.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Immunofluorescence (1:10000)
Immunoprecipitation (1:10000)
Western Blot (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In antiserum
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunofluorescence
Staining of KIF2A on HeLa cells fixed in 3.5% paraformaldehyde using KIF2A polyclonal antibody (Cat # PAB12407) (1 : 5,000). Centrosome staining during interphase and spindle pole staining during mitosis.Immunoprecipitation
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Gene Info — KIF2A
Entrez GeneID
3796Protein Accession#
O00139Gene Name
KIF2A
Gene Alias
HK2, KIF2
Gene Description
kinesin heavy chain member 2A
Omim ID
602591Gene Ontology
HyperlinkGene Summary
Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM
Other Designations
Kinesin, heavy chain, 2|kinesin heavy chain member 2
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Interactome
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Disease
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Publication Reference
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Α γ-tubulin complex-dependent pathway suppresses ciliogenesis by promoting cilia disassembly.
Sahana Shankar, Zi-Ting Hsu, Artur Ezquerra, Chien-Chien Li, Tzu-Lun Huang, Etienne Coyaud, Ricardo Viais, Cédric Grauffel, Brian Raught, Carmay Lim, Jens Lüders, Su-Yi Tsai, Kuo-Chiang Hsia.
Cell Reports 2022 Nov; 41(7):111642.
Application：IF, Human, HEK293T, SH-SY5Y cells.
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Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.
Lei Wang, Sharad C Paudyal, Yuchen Kang, Mikito Owa, Feng-Xia Liang, Alexander Spektor, Holger Knaut, Irma Sánchez, Brian D Dynlacht.
Cell Research 2022 Feb; 32(2):190.
Application：IF-Tr, Human, Human RPE cells.
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Cenpj regulates cilia disassembly and neurogenesis in the developing mouse cortex.
Ding W, Wu Q, Sun L, Pan NC, Wang X.
Journal of Neuroscience 2019 Mar; 39(11):1994.
Application：WB, Human, ARPE19 cells.
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DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement.
Jang CY, Wong J, Coppinger JA, Seki A, Yates JR 3rd, Fang G.
The Journal of Cell Biology 2008 Apr; 181(2):255.
Application：IF, WB-Tr, Human, HeLa cells.
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Prophase microtubule arrays undergo flux-like behavior in mammalian cells.
Ferenz NP, Wadsworth P.
Molecular Biology of the Cell 2007 Oct; 18(10):3993.
Application：IF, Human, LLC-Pk1-PA cells.
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The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK.
Ganem NJ, Compton DA.
The Journal of Cell Biology 2004 Aug; 166(4):473.
Application：IF, WB, Frog, Human, Mouse, CHO, Frog A6, HeLa, U-2 OS cells.
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Α γ-tubulin complex-dependent pathway suppresses ciliogenesis by promoting cilia disassembly.
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