LPIN1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LPIN1.
Immunogen
A synthetic peptide corresponding to amino acids 500-600 of human LPIN1.
Host
Rabbit
Reactivity
Human, Mouse, Primates, Rat
Form
Liquid
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of LPIN1 in 3T3-L1 lysate using LPIN1 polyclonal antibody (Cat # PAB12400). -
Gene Info — LPIN1
Entrez GeneID
23175Protein Accession#
Q14693Gene Name
LPIN1
Gene Alias
DKFZp781P1796, KIAA0188, PAP1
Gene Description
lipin 1
Omim ID
605518Gene Ontology
HyperlinkGene Summary
This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC Jr, Kelly DP.
Cell Metabolism 2006 Sep; 4(3):199.
Application:ChIP, WB, Mouse , Mouse hepatocytes.
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Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis.
Péterfy M, Phan J, Reue K.
The Journal of Biological Chemistry 2005 Sep; 280(38):32883.
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Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin.
Huffman TA, Mothe-Satney I, Lawrence JC Jr.
PNAS 2002 Jan; 99(2):1047.
Application:IP, Rat, Rat adipocytes.
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Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.
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