NBN polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant NBN.
Immunogen
Recombinant protein corresponding to amino acids 1-705 of human NBN.
Host
Rabbit
Reactivity
Human, Mouse, Primates
Specificity
This antibody is specific to human NBS1.
Form
Liquid
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:200)
Immunoprecipitation (3 ug/mL)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In antiserum (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
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Gene Info — NBN
Entrez GeneID
4683Protein Accession#
O60934Gene Name
NBN
Gene Alias
AT-V1, AT-V2, ATV, FLJ10155, MGC87362, NBS, NBS1, P95
Gene Description
nibrin
Gene Ontology
HyperlinkGene Summary
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq
Other Designations
Nijmegen breakage syndrome 1 (nibrin)|cell cycle regulatory protein p95|p95 protein of the MRE11/RAD50 complex
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Interactome
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Pathway
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Disease
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Publication Reference
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Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
Compton SA, Choi JH, Cesare AJ, Ozgür S, Griffith JD.
Cancer Research 2007 Feb; 67(4):1513.
Application:WB-Tr, Human, GM847, WI-Va13 cells.
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The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity.
Mirzoeva OK, Kawaguchi T, Pieper RO.
Molecular Cancer Therapeutics 2006 Nov; 5(11):2757.
Application:IP, WB, Human, U87 MG cells.
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Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.
McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S, Giavara S, O'Connor MJ, Tutt AN, Zdzienicka MZ, Smith GC, Ashworth A.
Cancer Research 2006 Aug; 66(16):8109.
Application:WB, Human, U-2 OS cells.
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Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
Gueven N, Becherel OJ, Birrell G, Chen P, DelSal G, Carney JP, Grattan-Smith P, Lavin MF.
Cancer Research 2006 Mar; 66(6):2907.
Application:WB, Human, ATL2ABR cells.
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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J.
Nature Cell Biology 2003 Mar; 5(3):255.
Application:WB, Human, U-2-OS cells.
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Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
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