Western Blot analysis of TNFRSF1B expression from cell extracts with TNFRSF1B polyclonal antibody (Cat # PAB12329). Lane 1 : MCF-7 whole cell lysate. Lane 2 : HeLa whole cell lysate. Lane 3 : MM453 whole cell lysate. Lane 4 : Jurkat whole cell lysate.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq