Western Blot analysis of SSX2 expression from cell extracts with SSX2 polyclonal antibody (Cat # PAB12322). Lane 1 : MM453 whole cell lysate. Lane 2 : MM231 whole cell lysate. Lane 3 : Jurkat whole cell lysate. Lane 4 : HT1080 whole cell lysate.
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
OTTHUMP00000024290,OTTHUMP00000024291,sarcoma, synovial, X-chromosome-related 2,synovial sarcoma, X breakpoint 2, isoform b,synovial sarcoma, X breakpoint 2B