RUNX2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RUNX2.
Immunogen
A synthetic peptide corresponding to amino acids 244-258 at middle region of human RUNX2.
Host
Rabbit
Theoretical MW (kDa)
55.6
Reactivity
Human, Rat
Specificity
Identical to the related rat and mouse sequence.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — RUNX2
Entrez GeneID
860Gene Name
RUNX2
Gene Alias
AML3, CBFA1, CCD, CCD1, MGC120022, MGC120023, OSF2, PEA2aA, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1
Gene Description
runt-related transcription factor 2
Gene Ontology
HyperlinkGene Summary
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq
Other Designations
CBF-alpha 1|OTTHUMP00000016533|SL3-3 enhancer factor 1 alpha A subunit|SL3/AKV core-binding factor alpha A subunit|acute myeloid leukemia 3 protein|core-binding factor, runt domain, alpha subunit 1|osteoblast-specific transcription factor 2|polyomavirus e
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Interactome
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Disease
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Publication Reference
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Human myeloma cell lines induce osteoblast downregulation of CD99 which is involved in osteoblast formation and activity.
Oranger A, Brunetti G, Carbone C, Colaianni G, Mongelli T, Gigante I, Tamma R, Mori G, Di Benedetto A, Sciandra M, Ventura S, Scotlandi K, Colucci S, Grano M.
Journal of Immunology Research 2015 Apr; 2015:156787.
Application：WB-Ce, Human, Osteoblasts.
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Identification of novel CBFA1/RUNX2 mutations causing cleidocranial dysplasia.
Bergwitz C, Prochnau A, Mayr B, Kramer FJ, Rittierodt M, Berten HL, Hausamen JE, Brabant G.
Journal of Inherited Metabolic Disease 2001 Nov; 24(6):648.
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Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice.
D'Souza RN, Aberg T, Gaikwad J, Cavender A, Owen M, Karsenty G, Thesleff I.
Development 1999 Jul; 126(13):2911.
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Human myeloma cell lines induce osteoblast downregulation of CD99 which is involved in osteoblast formation and activity.
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