AQP4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AQP4.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human AQP4.
Host
Rabbit
Theoretical MW (kDa)
34.4
Reactivity
Human, Mouse, Rat
Specificity
Identical to the related rat and mouse sequence.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of AQP4 expression from rat brain tissue lyate with AQP4 polyclonal antibody (Cat # PAB12309). -
Gene Info — AQP4
Entrez GeneID
361Gene Name
AQP4
Gene Alias
HMIWC2, MGC22454, MIWC
Gene Description
aquaporin 4
Omim ID
600308Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
aquaporin type4|aquaporin-4|mercurial-insensitive water channel
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Interactome
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Disease
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Publication Reference
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Aquaporin 4 expression and ultrastructure of the blood-brain barrier following cerebral contusion injury.
Li XJ, Han YY, Xu H, Sun ZS, Zhou ZJ, Long XD, Yang YM, Zou LB.
Neural Regeneration Research 2013 Feb; 8(4):338.
Application:IHC-P, Human, Brain.
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IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.
Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR.
The Journal of Experimental Medicine 2005 Aug; 202(4):473.
Application:IF, IP, Human, Mouse, Brain, Kidney, Stomach, HEK 293 cells.
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Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1.
Nagelhus EA, Mathiisen TM, Ottersen OP.
Neuroscience 2004 Jan; 129(4):905.
Application:IEM, Human, Brain.
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An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain.
Amiry-Moghaddam M, Otsuka T, Hurn PD, Traystman RJ, Haug FM, Froehner SC, Adams ME, Neely JD, Agre P, Ottersen OP, Bhardwaj A.
PNAS 2003 Feb; 100(4):2106.
Application:IEM, Mouse, Mouse cerebellum.
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Aquaporin 4 expression and ultrastructure of the blood-brain barrier following cerebral contusion injury.
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