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Last updated: 2017/8/20
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XAF1 polyclonal antibody

  • Catalog # : PAB12307
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of XAF1.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids at C-terminus of human XAF1.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 34.6
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • Identical to the related rat and mouse sequence.
  • Form:
  • Lyophilized
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Western Blot (1 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Western Blot
  • Western Blot analysis of XAF1 expression from cell and tissue extracts with XAF1 polyclonal antibody (Cat # PAB12307).
    Lane 1 : rat liver tissue lysate.
    Lane 2 : rat kidney tissue lysate.
    Lane 3 : rat spleen tissue lysate.
    Lane 4 : human placenta tissue lysate.
    Lane 5 : Marker.
    Lane 6 : MCF-7 whole cell lysate.
    Lane 7 : HeLa whole cell lysate.
    Lane 8 : smmc cell lysate.
    Lane 9 : HT1080 whole cell lysate.
    Lane 10 : Colo 320 whole cell lysate.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining of XAF1 on formalin fixed, paraffin embedded human epidermic carcinoma with XAF1 polyclonal antibody (Cat # PAB12307).
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Gene Name:
  • XAF1
  • Gene Alias:
  • BIRC4BP,HSXIAPAF1,XIAPAF1
  • Gene Description:
  • XIAP associated factor 1
  • Gene Summary:
  • X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3 BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623) activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells (Liston et al., 2001 [PubMed 11175744]).[supplied by OMIM
  • Other Designations:
  • BIRC4 binding protein
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