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Last updated: 2017/6/25
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NOTCH1 polyclonal antibody

  • Catalog # : PAB12305
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of NOTCH1.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids at internal region of human NOTCH1.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 272
  • Reactivity:
  • Human
  • Specificity:
  • Different from the related rat sequence by one amino acid.
  • Form:
  • Lyophilized
  • Purification:
  • Affinity purification
  • Isotype:
  • IgG
  • Recommend Usage:
  • Western Blot (1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blot analysis of NOTCH1 expression from cell extracts with NOTCH1 polyclonal antibody (Cat # PAB12305).
    Lane 1 : Marker.
    Lane 2 : MCF-7 whole cell lysate.
    Lane 3 : HeLa whole cell lysate.
    Lane 4 : Jurkat whole cell lysate.
    Lane 5 : Colo 320 whole cell lysate.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4851
  • Gene Name:
  • NOTCH1
  • Gene Alias:
  • TAN1,hN1
  • Gene Description:
  • Notch homolog 1, translocation-associated (Drosophila)
  • Gene Summary:
  • This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000022594,neurogenic locus notch homolog protein 1,notch1,translocation-associated notch protein TAN-1
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