PTGS2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTGS2.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human PTGS2.
Host
Rabbit
Theoretical MW (kDa)
68.9
Reactivity
Human, Mouse, Rat
Specificity
Different to the related rat sequence by two amino acids.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of PTGS2 on formalin fixed, paraffin embedded human mammary cancer with PTGS2 polyclonal antibody (Cat # PAB12301). -
Gene Info — PTGS2
Entrez GeneID
5743Gene Name
PTGS2
Gene Alias
COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Gene Description
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Omim ID
600262Gene Ontology
HyperlinkGene Summary
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq
Other Designations
OTTHUMP00000033524|cyclooxygenase 2b|prostaglandin G/H synthase and cyclooxygenase|prostaglandin-endoperoxide synthase 2
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Publication Reference
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Oxidative stress enzymes are changed in opioid abusers and multidrug abusers.
Sadat-Shirazi MS, Zarrindast MR, Ashabi G.
Journal of Clinical Neuroscience 2020 Feb; 72:365.
Application:WB-Ti, Human, Human brains.
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T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation.
Brewer JA, Khor B, Vogt SK, Muglia LM, Fujiwara H, Haegele KE, Sleckman BP, Muglia LJ.
Nature Medicine 2003 Oct; 9(10):1318.
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COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity.
Wilkinson-Berka JL, Alousis NS, Kelly DJ, Gilbert RE.
Investigative Ophthalmology & Visual Science 2003 Mar; 44(3):974.
Application:IHC-P, Mouse, Retina.
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Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice.
Liu CH, Chang SH, Narko K, Trifan OC, Wu MT, Smith E, Haudenschild C, Lane TF, Hla T.
The Journal of Biological Chemistry 2001 May; 276(21):18563.
Application:IHC, WB-Ti, Mouse, Mammary glands.
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Oxidative stress enzymes are changed in opioid abusers and multidrug abusers.
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