Rabbit polyclonal antibody raised against synthetic peptide of MMP16.
A synthetic peptide corresponding to amino acids at C-terminus of human MMP16.
Theoretical MW (kDa):
Human, Mouse, Rat
Identical to the related rat sequence. This antibody recognizes 69.5 KDa for MMP16 long form and 52.5 KDa for short form.
Western Blot (1-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) Immunohistochemistry (Frozen sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq