PPP2CA polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPP2CA.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human PPP2CA.
Host
Rabbit
Theoretical MW (kDa)
54.6, 57.6
Reactivity
Human, Mouse, Rat
Specificity
Identical to the related rat and mouse sequence.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
Immunocytochemistry (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of PPP2CA expression from rat kidney tissue lyate with PPP2CA polyclonal antibody (Cat # PAB12283).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of PPP2CA on formalin fixed, paraffin embedded human mammary cancer in cytoplasm DAB chromogenic reaction. Using PPP2CA polyclonal antibody (Cat # PAB12283).Immunocytochemistry
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Gene Info — PPP2CA
Entrez GeneID
5515Gene Name
PPP2CA
Gene Alias
PP2Ac, PP2CA, RP-C
Gene Description
protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Omim ID
176915Gene Ontology
HyperlinkGene Summary
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq
Other Designations
PP2A-alpha|protein phosphatase 2, catalytic subunit, alpha isoform|replication protein C|serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform|serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
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Interactome
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Pathway
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Disease
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Publication Reference
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Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function.
Gergs U, Boknik P, Buchwalow I, Fabritz L, Matus M, Justus I, Hanske G, Schmitz W, Neumann J.
The Journal of Biological Chemistry 2004 Sep; 279(39):40827.
Application:WB-Ti, Mouse, Mouse hearts.
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Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit.
Bryant JC, Westphal RS, Wadzinski BE.
The Biochemical Journal 1999 Apr; 339 ( Pt 2):241.
Application:WB-Re, Rat, Purified proteins from rat brains.
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Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.
Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT.
Cytogenetics and Cell Genetics 1993 Jun; 63(1):35.
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Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function.
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