CCR6 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CCR6.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human CCR6.
Host
Rabbit
Theoretical MW (kDa)
42.4
Reactivity
Human, Mouse, Rat
Specificity
Identical to the related rat and mouse sequence.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (0.75 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot
Western Blot analysis of CCR6 expression from cell and tissue extracts with CCR6 polyclonal antibody (Cat # PAB12270).
Lane 1 : rat thymus tissue lystae.
Lane 2 : MCF-7 whole cell lysate.
Lane 3 : HeLa whole cell lysate.
Lane 4 : smmc cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of CCR6 on formalin fixed, paraffin embedded rat intestine with CCR6 polyclonal antibody (Cat # PAB12270). -
Gene Info — CCR6
Entrez GeneID
1235Gene Name
CCR6
Gene Alias
BN-1, CD196, CKR-L3, CKR6, CKRL3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, GPRCY4, STRL22
Gene Description
chemokine (C-C motif) receptor 6
Omim ID
601835Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq
Other Designations
G protein-coupled receptor 29|OTTHUMP00000017618|OTTHUMP00000017619|chemokine (C-C) receptor 6|chemokine receptor-like 3|seven-transmembrane receptor, lymphocyte, 22
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Keratinocyte transglutaminase 2 promotes CCR6+ γδT-cell recruitment by upregulating CCL20 in psoriatic inflammation.
Ji-Woong Shin, Mee-Ae Kwon, Jinha Hwang, Seok-Jin Lee, Jin-Haeng Lee, Hyo-Jun Kim, Ki Baek Lee, Soo-Jin Lee, Eui Man Jeong, Jin Ho Chung, In-Gyu Kim.
Cell Death & Disease 2020 Apr; 11(4):301.
Application:IF, IHC-P, Mouse, Mouse skin tissues.
-
Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis.
Homey B, Dieu-Nosjean MC, Wiesenborn A, Massacrier C, Pin JJ, Oldham E, Catron D, Buchanan ME, Muller A, deWaal Malefyt R, Deng G, Orozco R, Ruzicka T, Lehmann P, Lebecque S, Caux C, Zlotnik A.
The Journal of Immunology 2000 Jun; 164(12):6621.
Application:Flow Cyt, Human, T cells.
-
Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27.
Liao F, Lee HH, Farber JM.
Genomics 1997 Feb; 40(1):175.
-
Molecular cloning and RNA expression of two new human chemokine receptor-like genes.
Zaballos A, Varona R, Gutiérrez J, Lind P, Márquez G.
Biochemical and Biophysical Research Communications 1996 Oct; 227(3):846.
-
Keratinocyte transglutaminase 2 promotes CCR6+ γδT-cell recruitment by upregulating CCL20 in psoriatic inflammation.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com