GRIN2B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRIN2B.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y1474 of human GRIN2B.
Sequence
HVYEK
Host
Rabbit
Theoretical MW (kDa)
190
Reactivity
Human, Mouse, Rat
Specificity
NMDAR2B (Ab-1472) antibody detects endogenous levels of total NMDAR2B protein.
Form
Liquid
Purification
Immunoaffinity purification
Concentration
1 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescence staining of methanol-fixed HeLa cells using GRIN2B polyclonal antibody (Cat # PAB12211, Red). -
Gene Info — GRIN2B
Entrez GeneID
2904Protein Accession#
Q13224Gene Name
GRIN2B
Gene Alias
MGC142178, MGC142180, NMDAR2B, NR2B, hNR3
Gene Description
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Omim ID
138252Gene Ontology
HyperlinkGene Summary
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq
Other Designations
N-methyl-D-aspartate receptor subunit 2B|glutamate receptor subunit epsilon-2
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Interactome
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Publication Reference
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The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies.
Chazot PL.
Current Medicinal Chemistry 2004 Feb; 11(3):389.
Application:WB-Tr, Human, Mouse, CHO, HEK 293 cells.
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Functional NMDA receptor channels generated by NMDAR2B gene transfer in rat cerebellar Purkinje cells.
Kakegawa W, Tsuzuki K, Iino M, Ozawa S.
The European Journal of Neuroscience 2003 Feb; 17(4):887.
Application:IF, IHC, Rat, Rat cerebellum.
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Brain plasticity and cellular mechanisms of epileptogenesis in human and experimental cortical dysplasia.
Babb TL, Ying Z, Mikuni N, Nishiyama K, Drazba J, Bingaman W, Wyllie E, Wylie CJ, Yacubova K.
Epilepsia 2000 Aug; 41 Suppl 6:S76.
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The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies.
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