GRIN2B (phospho Y1474) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of GRIN2B.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1474 of human GRIN2B.
Sequence
HVYpEK
Host
Rabbit
Theoretical MW (kDa)
190
Reactivity
Human, Mouse, Rat
Specificity
NMDAR2B (phospho-Tyr1474) antibody detects endogenous levels of NMDAR2B only when phosphorylated at Tyr1474.
Form
Liquid
Purification
Immunoaffinity purification
Concentration
1 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescence staining of methanol-fixed HeLa cells using GRIN2B (phospho Y1474) polyclonal antibody (Cat # PAB12171, red). -
Gene Info — GRIN2B
Entrez GeneID
2904Protein Accession#
Q13224Gene Name
GRIN2B
Gene Alias
MGC142178, MGC142180, NMDAR2B, NR2B, hNR3
Gene Description
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Omim ID
138252Gene Ontology
HyperlinkGene Summary
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq
Other Designations
N-methyl-D-aspartate receptor subunit 2B|glutamate receptor subunit epsilon-2
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Interactome
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Publication Reference
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Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development.
Liu XB, Murray KD, Jones EG.
Journal of Neuroscience 2004 Oct; 24(40):8885.
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Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex.
Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD.
Science 1999 Jul; 285(5424):93.
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Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies.
Tingley WG, Ehlers MD, Kameyama K, Doherty C, Ptak JB, Riley CT, Huganir RL.
The Journal of Biological Chemistry 1997 Feb; 272(8):5157.
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Switching of NMDA receptor 2A and 2B subunits at thalamic and cortical synapses during early postnatal development.
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