NOX4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of NOX4 in human kidney lysates with NOX4 polyclonal antibody at 2.0 ug/mL (Cat # PAB12095). A non-specific band is often observed running at 50 kDa in tissue lysates which is believed to correspond to the human IgG heavy chain.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NOX4.
Immunogen
A synthetic peptide corresponding to amino acids 100-200 of human NOX4.
Host
Rabbit
Reactivity
Bovine, Human, Mouse, Primates, Rat, Sheep
Form
Liquid
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL)
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of NOX4 in human kidney lysates with NOX4 polyclonal antibody at 2.0 ug/mL (Cat # PAB12095). A non-specific band is often observed running at 50 kDa in tissue lysates which is believed to correspond to the human IgG heavy chain.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
Immunocytochemistry
Immunofluorescence
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Gene Info — NOX4
Entrez GeneID
50507Protein Accession#
Q9NPH5Gene Name
NOX4
Gene Alias
KOX, KOX-1, RENOX
Gene Description
NADPH oxidase 4
Omim ID
605261Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants
Other Designations
kidney superoxide-producing NADPH oxidase|renal NAD(P)H-oxidase
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Interactome
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Disease
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Publication Reference
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Increased superoxide formation induced by irradiation preconditioning triggers kidney resistance to ischemia-reperfusion injury in mice.
Kim J, Park JW, Park KM.
American Journal of Physiology. Renal Physiology 2009 Feb; 296(5):F1202.
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Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma.
Maranchie JK, Zhan Y.
Cancer Research 2005 Oct; 65(20):9190.
Application：WB-Tr, Human, HEK 293 cells.
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Increased superoxide formation induced by irradiation preconditioning triggers kidney resistance to ischemia-reperfusion injury in mice.
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