Product Browser

Last updated: 2016/10/23
  • Related Product Showcase

Product Compare

Product Compare Cancel Click this icon to add products to compare list. Select up to 10 products.

Quick Order (Tutorial)

Input Catalog #,
place order here!
Catalog # :
  • Where to buy
  • Choose your location

NPC1 polyclonal antibody

  • Catalog # : PAB12093
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of NPC1.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 1230-1278 at C-terminus of human NPC1.
  • Host:
  • Rabbit
  • Reactivity:
  • Hamster, Human, Mouse
  • Specificity:
  • This antibody is specific to NPC1 protein.
  • Form:
  • Liquid
  • Recommend Usage:
  • Immunofluorescence (1:250)
    Western Blot (1:1000-1:3000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C for short term. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of NPC1 in 20 ug of human fibroblast cell lysate with NPC1 polyclonal antibody (Cat # PAB12093).
  • Immunohistochemistry
  • Immunofluorescence
  • Immunoprecipitation
  • Immunoelectron Microscopy
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry
  • Immunofluorescence
  • Immunoprecipitation
  • Immunoelectron Microscopy
  • Gene Information
  • Entrez GeneID:
  • 4864
  • Gene Name:
  • NPC1
  • Gene Alias:
  • NPC
  • Gene Description:
  • Niemann-Pick disease, type C1
  • Gene Summary:
  • This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments
  • Other Designations:
  • -
  • Gene Pathway
  • RSS
  • YouTube
  • Linkedin
  • Facebook