Npc1l1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of Npc1l1 in rat small intestine membrane preparations (Lane 1 : 2 ug/mL , Lane 2 : 4 ug/mL) with Npc1l1 polyclonal antibody (Cat # PAB12092).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Npc1l1.
Immunogen
A synthetic peptide corresponding to amino acids 1000-1100 of rat Npc1l1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to NPC1L1 protein.
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:100)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of Npc1l1 in rat small intestine membrane preparations (Lane 1 : 2 ug/mL , Lane 2 : 4 ug/mL) with Npc1l1 polyclonal antibody (Cat # PAB12092).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
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Gene Info — Npc1l1
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Publication Reference
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Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.
Liu W, Mani S, Davis NR, Sarrafzadegan N, Kavathas PB, Mani A.
Circulation Research 2008 Nov; 103(11):1280.
Application：WB, Mouse, Lymphoblastoid cells.
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Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake.
Montoudis A, Seidman E, Boudreau F, Beaulieu JF, Menard D, Elchebly M, Mailhot G, Sane AT, Lambert M, Delvin E, Levy E.
Journal of Lipid Research 2008 May; 49(5):961.
Application：WB-Ce, Human, Normal human intestinal epithelial cells.
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Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein.
Infante RE, Abi-Mosleh L, Radhakrishnan A, Dale JD, Brown MS, Goldstein JL.
The Journal of Biological Chemistry 2008 Jan; 283(2):1052.
Application：WB-Ce, Mouse, Mouse fibroblasts.
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CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine.
Nauli AM, Nassir F, Zheng S, Yang Q, Lo CM, Vonlehmden SB, Lee D, Jandacek RJ, Abumrad NA, Tso P.
Gastroenterology 2006 Oct; 131(4):1197.
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Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance.
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