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Last updated: 2017/5/28
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NUDT1 polyclonal antibody

  • Catalog # : PAB12088
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of NUDT1.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human NUDT1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • This antibody is specific to MTH1.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Immunocytochemistry (1:50-1:200)
    Immunofluorescence (1:50-1:200)
    Immunohistochemistry (Frozen sections) (1:200)
    Western Blot (1:500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C or -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of NUDT1 in NT2 cells (Lanes 1-3), and 833K64Cp9 cells (Lanes 4-5) with NUDT1 polyclonal antibody (Cat # PAB12088). Western Blot courtesy of Mark Kelley, Indiana University.
  • Immunohistochemistry (Frozen sections)
  • Immunocytochemistry
  • Immunofluorescence
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Frozen sections)
  • Immunocytochemistry
  • Immunofluorescence
  • Gene Information
  • Entrez GeneID:
  • 4521
  • Gene Name:
  • NUDT1
  • Gene Alias:
  • MTH1
  • Gene Description:
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • Gene Summary:
  • Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq
  • Other Designations:
  • 7,8-dihydro-8-oxoguanine triphosphatase,8-oxo-7,8-dihydrodeoxyguanosine triphosphatase,8-oxo-7,8-dihydroguanosine triphosphatase,8-oxo-dGTPase,OTTHUMP00000024690,OTTHUMP00000115537,OTTHUMP00000115538,OTTHUMP00000115539,OTTHUMP00000115540,mutT human homolo
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