NUDT1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of NUDT1 in NT2 cells (Lanes 1-3), and 833K64Cp9 cells (Lanes 4-5) with NUDT1 polyclonal antibody (Cat # PAB12088). Western Blot courtesy of Mark Kelley, Indiana University.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NUDT1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human NUDT1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to MTH1.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
Immunohistochemistry (Frozen sections) (1:200)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NUDT1 in NT2 cells (Lanes 1-3), and 833K64Cp9 cells (Lanes 4-5) with NUDT1 polyclonal antibody (Cat # PAB12088). Western Blot courtesy of Mark Kelley, Indiana University.Immunohistochemistry (Frozen sections)
Immunocytochemistry
Immunofluorescence
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Gene Info — NUDT1
Entrez GeneID
4521Gene Name
NUDT1
Gene Alias
MTH1
Gene Description
nudix (nucleoside diphosphate linked moiety X)-type motif 1
Omim ID
600312Gene Ontology
HyperlinkGene Summary
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq
Other Designations
7,8-dihydro-8-oxoguanine triphosphatase|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase|8-oxo-7,8-dihydroguanosine triphosphatase|8-oxo-dGTPase|OTTHUMP00000024690|OTTHUMP00000115537|OTTHUMP00000115538|OTTHUMP00000115539|OTTHUMP00000115540|mutT human homolo
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Interactome
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Disease
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Publication Reference
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Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence.
Rai P, Onder TT, Young JJ, McFaline JL, Pang B, Dedon PC, Weinberg RA.
PNAS 2008 Dec; 106(1):169.
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Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue.
Kennedy CH, Pass HI, Mitchell JB.
Free Radical Biology & Medicine 2003 Jun; 34(11):1447.
Application：IHC-Fr, WB, Human, Human lung adenocarcinoma.
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Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Takeshita F, Ogawa K, Asamoto M, Shirai T.
Cancer Letters 2003 May; 194(1):25.
Application：WB-Ti, Rat, Rat livers.
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Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence.
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