OGG1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of OGG1 in HeLa and Jurkat cell lysate with OGG1 polyclonal antibody (Cat # PAB12085).
Western Blot (Recombinant protein)
Western blot analysis of OGG1 of 1, 5, 10 ng titration of human recombinant Ogg1 protein with OGG1 polyclonal antibody (Cat # PAB12085).
Immunohistochemistry (Frozen sections)
Immunohistochemical staining of OGG1 on formaldehyde fixed frozen sections of the substantia nigra from a Rhesus macaque with OGG1 polyclonal antibody (Cat # PAB12085). Photo courtesy of Glen Kisby, Oregon Health Sciences University. The tissue was a generous gift of Dr. Steven Kohama, Oregon National Primate Research Center.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of OGG1.
Immunogen
A synthetic peptide corresponding to amino acids 1-100 of human OGG1.
Host
Rabbit
Reactivity
Human, Primates, Rat
Specificity
This antibody is specific to human Ogg1.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:1000)
Immunohistochemistry (Frozen sections) (1:25-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of OGG1 in HeLa and Jurkat cell lysate with OGG1 polyclonal antibody (Cat # PAB12085).Western Blot (Recombinant protein)
Western blot analysis of OGG1 of 1, 5, 10 ng titration of human recombinant Ogg1 protein with OGG1 polyclonal antibody (Cat # PAB12085).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunohistochemical staining of OGG1 on formaldehyde fixed frozen sections of the substantia nigra from a Rhesus macaque with OGG1 polyclonal antibody (Cat # PAB12085). Photo courtesy of Glen Kisby, Oregon Health Sciences University. The tissue was a generous gift of Dr. Steven Kohama, Oregon National Primate Research Center. -
Gene Info — OGG1
Entrez GeneID
4968Gene Name
OGG1
Gene Alias
HMMH, HOGG1, MUTM, OGH1
Gene Description
8-oxoguanine DNA glycosylase
Gene Ontology
HyperlinkGene Summary
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq
Other Designations
8-hydroxyguanine DNA glycosylase|OTTHUMP00000122619
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Interactome
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Pathway
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Disease
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Publication Reference
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The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord.
Roseborough G, Gao D, Chen L, Trush MA, Zhou S, Williams GM, Wei C.
The American Journal of Pathology 2006 May; 168(5):1443.
Application：IHC-P, WB-Ti, Rabbit, Rabbit spinal cord.
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Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria.
Rachek LI, Thornley NP, Grishko VI, LeDoux SP, Wilson GL.
Diabetes 2006 Apr; 55(4):1022.
Application：WB, Rat, INS-1 cells.
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The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells.
Chen D, Yu Z, Zhu Z, Lopez CD.
Cancer Research 2006 Apr; 66(7):3485.
Application：WB-Ce, Human, HCT-116 cells.
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beta(2)-Adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy.
Xydas S, Kherani AR, Chang JS, Klotz S, Hay I, Mutrie CJ, Moss GW, Gu A, Schulman AR, Gao D, Hu D, Wu EX, Wei C, Oz MC, Wang J.
The Journal of Pharmacology and Experimental Therapeutics 2006 May; 317(2):553.
Application：IHC-P, Rat, Rat hearts.
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The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord.
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