OS9 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of OS9 in lysates of 293 cells expressing OS-9.1 and OS-9.2 with OS9 polyclonal antibody (Cat # PAB12082).
Immunohistochemistry
Immunohistochemical staining of OS9 on mouse smooth muscle using with OS9 polyclonal antibody (Cat # PAB12082).
Immunoprecipitation
Immunoprecipitation of OS9 in 293 cells expressing OS9.1 and OS9.2 with OS9 polyclonal antibody (Cat # PAB12082).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of OS9.
Immunogen
A synthetic peptide corresponding to amino acids 300-400 of human OS9.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to isoforms 1 and 2 of human OS-9.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunofluorescence (0.2-1 ug/mL)
Immunohistochemistry (0.5-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:250)
Western Blot (0.2-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.01% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of OS9 in lysates of 293 cells expressing OS-9.1 and OS-9.2 with OS9 polyclonal antibody (Cat # PAB12082).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
Immunohistochemical staining of OS9 on mouse smooth muscle using with OS9 polyclonal antibody (Cat # PAB12082).Immunofluorescence
Immunoprecipitation
Immunoprecipitation of OS9 in 293 cells expressing OS9.1 and OS9.2 with OS9 polyclonal antibody (Cat # PAB12082). -
Gene Info — OS9
Entrez GeneID
10956Protein Accession#
Q13438Gene Name
OS9
Gene Alias
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Gene Description
amplified in osteosarcoma
Omim ID
609677Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal.
Bernasconi R, Pertel T, Luban J, Molinari M.
The Journal of Biological Chemistry 2008 Apr; 283(24):16446.
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A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal.
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