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Last updated: 2018/1/14
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PDHA1 (phospho S293) polyclonal antibody

  • Catalog # : PAB12079
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of PDHA1.
  • Immunogen:
  • Synthetic phosphopeptide corresponding to residues surrounding S293 human PDHA1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific to the phosphorylated Serine 293 form of the PDHE1 alpha protein.
  • Form:
  • Liquid
  • Recommend Usage:
  • Immunocytochemistry (1:50-1:200)
    Immunofluorescence (1:50-1:200)
    Western Blot (1:1000-1:5000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Western Blot
  • Western blot analysis of PDHA1 in an in vitro autophosphorylation of PDH complex in response to different stimulants with PDHA1 (phospho S293) polyclonal antibody (Cat # PAB12079).
    Such stimulants are : (-) none, H2O2-hydrogen peroxide, AR-anhydroretinol, Rol-retinol, RA-retinoic acid, PMA, Lipid-PKC lipid activator.
    Photo courtesy of Dr. Beatrice Hoyos, Memorial Sloan-Kettering Cancer Center.
  • Immunocytochemistry
  • Immunofluorescence
  • Application Image
  • Immunocytochemistry
  • Immunofluorescence
  • Gene Information
  • Entrez GeneID:
  • 5160
  • Gene Name:
  • PDHA1
  • Gene Alias:
  • Gene Description:
  • pyruvate dehydrogenase (lipoamide) alpha 1
  • Gene Summary:
  • The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1); dihydrolipoyl transacetylase (DLAT; MIM 608770) (E2; EC; and dihydrolipoyl dehydrogenase (DLD; MIM 238331) (E3; EC The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994 [PubMed 7853374]).[supplied by OMIM
  • Other Designations:
  • OTTHUMP00000023015,pyruvate dehydrogenase E1 alpha subunit
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