POT1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of POT1 in HeLa nuclear extracts (25 ug) with POT1 polyclonal antibody (Cat # PAB12064).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of POT1.
Immunogen
A synthetic peptide corresponding to amino acids 200-300 of human POT1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to POT1.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl
Storage Instruction
Store at 4°C. Do not freeze.
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Applications
Western Blot (Cell lysate)
Western blot analysis of POT1 in HeLa nuclear extracts (25 ug) with POT1 polyclonal antibody (Cat # PAB12064). -
Gene Info — POT1
Entrez GeneID
25913Gene Name
POT1
Gene Alias
DKFZp586D211, hPot1
Gene Description
POT1 protection of telomeres 1 homolog (S. pombe)
Omim ID
606478Gene Ontology
HyperlinkGene Summary
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq
Other Designations
POT1-like telomere end-binding protein|protection of telomeres 1
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Interactome
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Disease
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Publication Reference
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Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.
Yang Q, Zhang R, Horikawa I, Fujita K, Afshar Y, Kokko A, Laiho P, Aaltonen LA, Harris CC.
Cancer Research 2007 Dec; 67(24):11677.
Application：WB-Ce, Human, HT1080 cells.
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Telomere maintenance through spatial control of telomeric proteins.
Chen LY, Liu D, Songyang Z.
Molecular and Cellular Biology 2007 Aug; 27(16):5898.
Application：WB, Human, HTC75 cells.
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Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.
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