PPARGC1A polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPARGC1A.
Immunogen
A synthetic peptide corresponding to amino acids 400-550 of human PPARGC1A.
Host
Rabbit
Reactivity
Dog, Horse, Human, Mouse, Primates, Rat
Form
Liquid
Purification
Immunogen affinity purification
Recommend Usage
Immunofluorescence (1:1000)
Immunohistochemistry (1:200-1:500)
Immunoprecipitation
Western Blot (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of PPARGC1A in human liver with PPARGC1A polyclonal antibody (Cat # PAB12061).Immunohistochemistry
Immunofluorescence
Immunoprecipitation
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Gene Info — PPARGC1A
Entrez GeneID
10891Protein Accession#
Q9UBK2Gene Name
PPARGC1A
Gene Alias
LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1
Gene Description
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Omim ID
604517Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq
Other Designations
OTTHUMP00000123372|PPAR gamma coactivator variant form|PPAR gamma coactivator-1|ligand effect modulator-6|peroxisome proliferative activated receptor, gamma, coactivator 1, alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-induced Liver Injury in Aged Mice.
Hui Qian, Xiaojuan Chao, Shaogui Wang, Yuan Li, Xiaoxiao Jiang, Zhaoli Sun, Thomas Rülicke, Kurt Zatloukal , Hong-Min Ni , Wen-Xing Ding.
Cellular and Molecular Gastroenterology and Hepatology 2023 Feb; 15(5):1027.
Application:WB-Ti, Mouse, Mouse liver.
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Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation.
Xiaowen Ma, Allen Chen, Luma Melo, Ana Clemente-Sanchez, Xiaojuan Chao, Ali Reza Ahmadi, Brandon Peiffer, Zhaoli Sun, Hiromi Sesaki, Tiangang Li, Xiaokun Wang, Wanqing Liu, Ramon Bataller, Hong-Min Ni, Wen-Xing Ding
Hepatology 2022 Jul; 77(1):159.
Application:WB, Mouse, Mouse liver.
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Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans.
Wang S, Ni HM, Chao X, Ma X, Kolodecik T, De Lisle R, Ballabio A, Pacher P, Ding WX.
Cellular and Molecular Gastroenterology and Hepatology 2020 Jan; 10(1):59.
Application:WB-Ti, Mouse, Mouse pancreatic tissues.
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Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice.
Chao X, Wang S, Zhao K, Li Y, Williams JA, Li T, Chavan H, Krishnamurthy P, He XC, Li L, Ballabio A, Ni HM, Ding WX.
Gastroenterology 2018 May; [Epub].
Application:WB-Ti, Mouse, Liver.
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PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.
Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM.
Genes & Development 2007 Apr; 21(7):770.
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Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-induced Liver Injury in Aged Mice.
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