PTGDS polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of PTGDS in human brain lysates with PTGDS polyclonal antibody at 0.5 and 2.0 ug/mL (Cat # PAB12055).
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant PTGDS.
Immunogen
Recombinant protein corresponding to amino acids 120-190 of human PTGDS.
Host
Rabbit
Reactivity
Bovine, Cat, Dog, Human, Mouse, Primates, Rabbit, Rat
Specificity
The epitope recognized by this antibody maps to region within residue 120-190 of human PTGDS. [Swiss-Prot# P41222]
Form
Liquid
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of PTGDS in human brain lysates with PTGDS polyclonal antibody at 0.5 and 2.0 ug/mL (Cat # PAB12055). -
Gene Info — PTGDS
Entrez GeneID
5730Protein Accession#
P41222Gene Name
PTGDS
Gene Alias
LPGDS, PDS, PGD2, PGDS, PGDS2
Gene Description
prostaglandin D2 synthase 21kDa (brain)
Omim ID
176803Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq
Other Designations
OTTHUMP00000022638|PGD2 synthase|beta-trace protein|glutathione-independent PGD synthase|lipocalin-type prostaglandin D synthase|prostaglandin D synthase|prostaglandin D2 synthase (21kD, brain)|prostaglandin H2 D-isomerase|prostaglandin-H2 D-isomerase
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Interactome
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Pathway
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Disease
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Publication Reference
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Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid.
Kanekiyo T, Ban T, Aritake K, Huang ZL, Qu WM, Okazaki I, Mohri I, Murayama S, Ozono K, Taniike M, Goto Y, Urade Y.
PNAS 2007 Apr; 104(15):6412.
Application：IF, IHC-P, Mouse, Frontal cortex from a patient with Alzheimer's disease , Mouse cerebral cortex.
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Lipocalin-type prostaglandin D synthase/beta-trace is a major amyloid beta-chaperone in human cerebrospinal fluid.
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