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Last updated: 2016/12/4
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RAD50 polyclonal antibody

  • Catalog # : PAB12052
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against partial recombinant RAD50.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 628-787 of human RAD50.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific to human Rad50.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • Western Blot (1:1000-1:10000)
    Immunoprecipitation (1-5 ug/mL lysate)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • No additive
  • Storage Instruction:
  • Store at 4°C for short term. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot
  • Western Blot
  • Western blot analysis of RAD50 in 25 ng purified hMre11-hRAD50 complex (Lane 1) and 25 ug crude HeLa extract (Lane 2 :) with RAD50 polyclonal antibody (Cat # PAB12052).
  • Immunoprecipitation
  • Application Image
  • Immunoprecipitation
  • Gene Information
  • Gene Name:
  • RAD50
  • Gene Alias:
  • RAD50-2,hRad50
  • Gene Description:
  • RAD50 homolog (S. cerevisiae)
  • Gene Summary:
  • The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000065928,RAD50 homolog
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