SIRT7 immunoprecipitated from human liver lysates with SIRT7 polyclonal antibody (Cat # PAB12034) and further Western blotted with (A) SIRT7 polyclonal antibody (Cat # PAB12033) (B) SIRT7 polyclonal antibody (Cat # PAB12033).
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq
silent mating type information regulation 2, S.cerevisiae, homolog 7,sir2-related protein type 7,sirtuin 7,sirtuin type 7