SREBF1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of SREBF1 in human liver (Lane 1) and mouse liver (Lane 2) with SREBF1 polyclonal antibody (Cat # PAB12020).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SREBF1.
Immunogen
A synthetic peptide corresponding to amino acids 300-400 of human SREBF1.
Host
Rabbit
Reactivity
Bovine, Goat, Human, Mouse, Pig, Rat, Sheep
Specificity
This antibody is specific to SREBP1.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SREBF1 in human liver (Lane 1) and mouse liver (Lane 2) with SREBF1 polyclonal antibody (Cat # PAB12020). -
Gene Info — SREBF1
Entrez GeneID
6720Gene Name
SREBF1
Gene Alias
SREBP-1c, SREBP1, bHLHd1
Gene Description
sterol regulatory element binding transcription factor 1
Omim ID
184756Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
sterol regulatory element binding protein-1
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Interactome
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Pathway
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Disease
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Publication Reference
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Knock-down of circular RNA H19 induces human adipose-derived stem cells adipogenic differentiation via a mechanism involving the polypyrimidine tract-binding protein 1.
Zhu Y, Gui W, Lin X, Li H.
Experimental Cell Research 2019 Dec; 387(2):111753.
Application：IF, WB, Human, ADSC cells.
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Knock-down of circular RNA H19 induces human adipose-derived stem cells adipogenic differentiation via a mechanism involving the polypyrimidine tract-binding protein 1.
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