TPX2 polyclonal antibody
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More Files
- More Functions
Immunofluorescence
Immunofluorescence staining of TPX2 on nuclears of HeLa cells fixed in 3.5% paraformaldehyde during interphase and spindle staining during mitosis with TPX2 polyclonal antibody at 1 : 1000 (Cat # PAB11993).
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant TPX2.
Immunogen
Recombinant protein corresponding to C-terminus of human TPX2.
Host
Rabbit
Reactivity
Human, Mammals, Mouse, Rat
Specificity
This antibody is specific to TPX2.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Immunofluorescence (1:1000)
Immunoprecipitation (1:1000)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In antiserum
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunofluorescence
Immunofluorescence staining of TPX2 on nuclears of HeLa cells fixed in 3.5% paraformaldehyde during interphase and spindle staining during mitosis with TPX2 polyclonal antibody at 1 : 1000 (Cat # PAB11993).Immunoprecipitation
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Gene Info — TPX2
Entrez GeneID
22974Gene Name
TPX2
Gene Alias
C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100
Gene Description
TPX2, microtubule-associated, homolog (Xenopus laevis)
Omim ID
605917Gene Ontology
HyperlinkGene Summary
microtubule-associated
Other Designations
TPX2, microtubule-associated protein homolog|differentially expressed in lung cells|hepatocellular carcinoma-associated antigen 519|preferentially expressed in colorectal cancer|restricted expression proliferation associated protein 100|targeting protein
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Interactome
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Disease
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Publication Reference
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Differences in Mitotic Spindle Architecture in Mammalian Neural Stem Cells Influence Mitotic Accuracy during Brain Development.
Vargas-Hurtado D, Brault JB, Piolot T, Leconte L, Da Silva N, Pennetier C, Baffet A, Marthiens V, Basto R.
Current Biology : CB 2019 Sep; 29(18):2993.
Application：Flow Cyt, IF, WB, Mouse, Cortical explants, Neural stem cells.
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Prognostic significance of TPX2 and NIBP in esophageal cancer.
Sui C, Song Z, Yu H, Wang H.
Oncology Letters 2019 Oct; 18(4):4221.
Application：WB-Ti, Human, Human esophageal cancer.
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MicroRNA-1294 inhibits the proliferation and enhances the chemosensitivity of glioma to temozolomide via the direct targeting of TPX2.
Chen H, Liu L, Li X, Shi Y, Liu N.
American Journal of Cancer Research 2018 Feb; 8(2):291.
Application：WB-Ti, WB-Tr, Human, Mouse, Mouse tumors, U251 cells.
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Disruption of mouse cenpj, a regulator of centriole biogenesis, phenocopies seckel syndrome.
McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F; Sanger Mouse Genetics Project, Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F, Adams DJ.
PLoS Genetics 2012 Nov; 8(11):e1003022.
Application：IF, Mouse, MEFs, Mouse embryonic fibroblasts.
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Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A.
Bird AW, Hyman AA.
The Journal of Cell Biology 2008 Jul; 182(2):289.
Application：WB, Human, U-2 OS cells.
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A survivin-ran complex regulates spindle formation in tumor cells.
Xia F, Canovas PM, Guadagno TM, Altieri DC.
Molecular and Cellular Biology 2008 Jun; 28(17):5299.
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Tumor cell dependence on Ran-GTP-directed mitosis.
Xia F, Lee CW, Altieri DC.
Cancer Research 2008 Mar; 68(6):1826.
Application：IF, Human, HeLa cells.
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Differences in Mitotic Spindle Architecture in Mammalian Neural Stem Cells Influence Mitotic Accuracy during Brain Development.
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