Trpm2 polyclonal antibody
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More Files
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Western Blot
Western blot analysis of Trpm2 in CHO cells untransfected (Lane 1), CHO cell transfected with rat TRPM2 (Lane 2) and mouse cortical neurons (cultured) (Lane 3) with Trpm2 polyclonal antibody (Cat # PAB11990). Photo courtesy of Dr. Paco Herson, Oregon Health & Science University.
Immunohistochemistry
Immunohistochemical staining of Trpm2 on rat hippocampus with Trpm2 polyclonal antibody (Cat # PAB11990). TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Trpm2.
Immunogen
A synthetic peptide corresponding to amino acids 1430-1508 of rat Trpm2.
Host
Rabbit
Reactivity
Mouse, Rat
Specificity
This antibody is specific to isoform 1, or the long isoform (TRPM2-L), of TRPM2.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:200)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Trpm2 in CHO cells untransfected (Lane 1), CHO cell transfected with rat TRPM2 (Lane 2) and mouse cortical neurons (cultured) (Lane 3) with Trpm2 polyclonal antibody (Cat # PAB11990). Photo courtesy of Dr. Paco Herson, Oregon Health & Science University.Immunohistochemistry
Immunohistochemical staining of Trpm2 on rat hippocampus with Trpm2 polyclonal antibody (Cat # PAB11990). TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand. -
Gene Info — Trpm2
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Publication Reference
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TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.
Zhang W, Hirschler-Laszkiewicz I, Tong Q, Conrad K, Sun SC, Penn L, Barber DL, Stahl R, Carey DJ, Cheung JY, Miller BA.
American Journal of Physiology. Cell Physiology 2006 Apr; 290(4):C1146.
Application：IF, WB-Tr, Human, U937-ecoR cells.
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A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death.
Zhang W, Chu X, Tong Q, Cheung JY, Conrad K, Masker K, Miller BA.
The Journal of Biological Chemistry 2003 May; 278(18):16222.
Application：IF, IP, WB-Tr, Human, HEK 293T, TF-1 cells.
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TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.
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