WNK4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of WNK4 in mouse kidney lysate with WNK4 polyclonal antibody (Cat # PAB11980).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of WNK4.
Immunogen
A synthetic peptide corresponding to amino acids 200-300 of human WNK4.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to WNK4 protein.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot analysis of WNK4 in mouse kidney lysate with WNK4 polyclonal antibody (Cat # PAB11980). -
Gene Info — WNK4
Entrez GeneID
65266Gene Name
WNK4
Gene Alias
PHA2B, PRKWNK4
Gene Description
WNK lysine deficient protein kinase 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB
Other Designations
protein kinase, lysine deficient 4
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Disease
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Publication Reference
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Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats.
Song J, Hu X, Riazi S, Tiwari S, Wade JB, Ecelbarger CA.
American Journal of Physiology. Renal Physiology 2006 May; 290(5):F1055.
Application：WB-Ti, Rat, Kidney, Cortex.
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WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.
Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP.
PNAS 2004 Feb; 101(7):2064.
Application：IF, WB-Ti, Human, Mouse, Kidney, Brain, Testis, Colon, Heart, Liver, Prostate, Lung, Breast, Ovary, Colon, Melanocytes, Muscle, Skin, Pancreas.
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Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats.
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