XRCC3 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of XRCC3.
Immunogen
A synthetic peptide corresponding to human XRCC3.
Host
Rabbit
Theoretical MW (kDa)
38
Reactivity
Human
Specificity
This antibody is specific to XRCC3. This antibody is useful for Western blot, where a band can be seen at 38 kDa. No cross-reactivity was observed with XRCC2, RAD51, RAD51B, RAD51C, or RAD51D. The antibody is not applicable for Immunocytochemistry/Immunofluorescence.
Form
Liquid
Purification
Immunogen affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunoprecipitation
Western Blot (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of XRCC3 in HTC116 and HeLa whole cell extracts with XRCC3 polyclonal antibody at 1 : 2500 (Cat # PAB11977).Immunoprecipitation
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Gene Info — XRCC3
Entrez GeneID
7517Protein Accession#
O43542Gene Name
XRCC3
Gene Alias
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Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 3
Omim ID
600675Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq
Other Designations
DNA repair protein XRCC3|RAD51-like|X-ray repair cross complementing protein 3|X-ray-repair, complementing defective, repair in Chinese hamster
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Interactome
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Pathway
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Disease
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Publication Reference
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Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
Compton SA, Choi JH, Cesare AJ, Ozgür S, Griffith JD.
Cancer Research 2007 Feb; 67(4):1513.
Application:WB-Tr, Human, GM847, WI-Va13 cells.
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Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C.
Nagaraju G, Odate S, Xie A, Scully R.
Molecular and Cellular Biology 2006 Nov; 26(21):8075.
Application:WB-Tr, Mouse , CHO-AA8, cells.
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Role for RAD18 in homologous recombination in DT40 cells.
Szuts D, Simpson LJ, Kabani S, Yamazoe M, Sale JE.
Molecular Biology of the Cell 2006 Nov; 26(21):8032.
Application:WB, Chicken, DT40 Cells.
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XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells.
Yoshihara T, Ishida M, Kinomura A, Katsura M, Tsuruga T, Tashiro S, Asahara T, Miyagawa K.
The EMBO Journal 2004 Feb; 23(3):670.
Application:WB, Human, HCT-116 cells.
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Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
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