ZMPSTE24 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of ZMPSTE24 in human testis with ZMPSTE24 polyclonal antibody (Cat # PAB11974).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ZMPSTE24.
Immunogen
A synthetic peptide corresponding to amino acids 400-475 of human ZMPSTE24.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to ZMPSTE24.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl (0.05% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ZMPSTE24 in human testis with ZMPSTE24 polyclonal antibody (Cat # PAB11974). -
Gene Info — ZMPSTE24
Entrez GeneID
10269Protein Accession#
O75844Gene Name
ZMPSTE24
Gene Alias
FACE-1, FACE1, FLJ14968, STE24, Ste24p
Gene Description
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq
Other Designations
CAAX prenyl protease|OTTHUMP00000006394|farnesylated-proteins converting enzyme 1|prenyl protein-specific endoprotease 1|zinc metalloproteinase STE24
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Interactome
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Disease
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Publication Reference
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Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.
Young SG, Fong LG, Michaelis S.
Journal of Lipid Research 2005 Dec; 46(12):2531.
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Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24.
Corrigan DP, Kuszczak D, Rusinol AE, Thewke DP, Hrycyna CA, Michaelis S, Sinensky MS.
The Biochemical Journal 2005 Apr; 387(Pt 1):129.
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Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.
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