MADD polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MADD.
Immunogen
A synthetic peptide corresponding to amino acids 1570-1588 of human MADD.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody recognizes human and mouse MADD (200-220 kD). This peptide sequence is identical to that of DENN and differs by one amino acid with rat GDP/GTP exchange protein RAB3-GEP.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:250-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — MADD
Entrez GeneID
8567Protein Accession#
AAD12154Gene Name
MADD
Gene Alias
DENN, FLJ35600, FLJ36300, IG20, KIAA0358, RAB3GEP
Gene Description
MAP-kinase activating death domain
Omim ID
603584Gene Ontology
HyperlinkGene Summary
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
MAP-kinase activating death domain-containing protein|Rab3 GDP/GTP exchange factor|differentially expressed in normal and neoplastic cells|insulinoma-glucagonoma protein 20
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Interactome
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Disease
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