ARNTL polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ARNTL.
Immunogen
A synthetic peptide corresponding to human ARNTL.
Sequence
REKITTNCYKFKIKD
Host
Goat
Theoretical MW (kDa)
68.7, 64.1
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ARNTL polyclonal antibody (Cat # PAB11615) (0.3 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ARNTL
Entrez GeneID
406Protein Accession#
NP_001169.3;NP_001025444.1Gene Name
ARNTL
Gene Alias
BMAL1, BMAL1c, JAP3, MGC47515, MOP3, PASD3, TIC, bHLHe5
Gene Description
aryl hydrocarbon receptor nuclear translocator-like
Omim ID
602550Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
ARNT-like protein 1, brain and muscle|bHLH-PAS protein JAP3|basic-helix-loop-helix-PAS orphan MOP3|member of PAS superfamily 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Differential rescue of light- and food-entrainable circadian rhythms.
Fuller PM, Lu J, Saper CB.
Science 2008 May; 320(5879):1074.
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Differential rescue of light- and food-entrainable circadian rhythms.
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