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Last updated: 2016/12/4
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NR1I2 polyclonal antibody

  • Catalog # : PAB11612
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of NR1I2.
  • Immunogen:
  • A synthetic peptide corresponding to human NR1I2.
  • Sequence:
  • EQFAITLKSYIECNR
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 49.8, 53.9, 45.8
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:4000)
    Western Blot (1-3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • NR1I2 polyclonal antibody (Cat # PAB11612) (1 ug/mL) staining of HepG2 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 8856
  • Protein Accession#:
  • NP_003880.3;NP_071285.1;NP_148934.1
  • Gene Name:
  • NR1I2
  • Gene Alias:
  • BXR,ONR1,PAR,PAR1,PAR2,PARq,PRR,PXR,SAR,SXR
  • Gene Description:
  • nuclear receptor subfamily 1, group I, member 2
  • Gene Summary:
  • This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq
  • Other Designations:
  • orphan nuclear receptor PXR,steroid and xenobiotic receptor
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