SLC26A5 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SLC26A5.
Immunogen
A synthetic peptide corresponding to human SLC26A5.
Sequence
ERLHTKDKVPDSIAD-C
Host
Goat
Theoretical MW (kDa)
81.3, 74.8, 56.5, 36
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SLC26A5
Entrez GeneID
375611Protein Accession#
NP_945350.1;NP_996766.1;NP_996767.1;NP_996768.1Gene Name
SLC26A5
Gene Alias
DFNB61, MGC118886, MGC118887, MGC118888, MGC118889, PRES
Gene Description
solute carrier family 26, member 5 (prestin)
Omim ID
604943Gene Ontology
HyperlinkGene Summary
This gene is a member of the SLC26A/SulP transporter family. It encodes a protein that is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. Intracellular anions are thought to act as extrinsic voltage sensors, which bind to this protein and trigger the conformational changes required for rapid length changes in OHCs. Mutations in this gene have been associated with non-syndromic hearing loss. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
OTTHUMP00000195086|deafness, neurosensory, autosomal recessive, 61|prestin|prestin (motor protein)
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Disease
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Publication Reference
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Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification.
Dallos P, Wu X, Cheatham MA, Gao J, Zheng J, Anderson CT, Jia S, Wang X, Cheng WH, Sengupta S, He DZ, Zuo J.
Neuron 2008 May; 58(3):333.
Application：ICC, IF, WB, Mouse, A pair of cochleae from WT and 499/499 mouse, Mouse outer hair cells.
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Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification.
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