TMPRSS2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
TMPRSS2 polyclonal antibody (Cat # PAB11593) (0.1 ug/mL) staining of human pancreas Lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TMPRSS2.
Immunogen
A synthetic peptide corresponding to human TMPRSS2.
Sequence
C-TDWIYRQMRADG
Host
Goat
Theoretical MW (kDa)
53.9
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
TMPRSS2 polyclonal antibody (Cat # PAB11593) (0.1 ug/mL) staining of human pancreas Lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TMPRSS2
Entrez GeneID
7113Protein Accession#
NP_005647.2Gene Name
TMPRSS2
Gene Alias
FLJ41954, PP9284, PRSS10
Gene Description
transmembrane protease, serine 2
Omim ID
602060Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
epitheliasin
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Interactome
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Disease
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Publication Reference
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Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer.
Tomlins SA, Laxman B, Dhanasekaran SM, Helgeson BE, Cao X, Morris DS, Menon A, Jing X, Cao Q, Han B, Yu J, Wang L, Montie JE, Rubin MA, Pienta KJ, Roulston D, Shah RB, Varambally S, Mehra R, Chinnaiyan AM.
Nature 2007 Aug; 448(7153):595.
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Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer.
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