OTUB1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
OTUB1 polyclonal antibody (Cat # PAB11566) (0.05 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of OTUB1.
Immunogen
A synthetic peptide corresponding to human OTUB1.
Sequence
C-YKEYAEDDNIYQQK
Host
Goat
Theoretical MW (kDa)
31.3
Reactivity
Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.03-0.1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
OTUB1 polyclonal antibody (Cat # PAB11566) (0.05 ug/mL) staining of mouse brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — OTUB1
Entrez GeneID
55611Protein Accession#
NP_060140.2Gene Name
OTUB1
Gene Alias
FLJ20113, FLJ40710, HSPC263, MGC111158, MGC4584, OTB1, OTU1
Gene Description
OTU domain, ubiquitin aldehyde binding 1
Omim ID
608337Gene Ontology
HyperlinkGene Summary
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTU-domain Ubal-binding 1|otubain 1|ubiquitin-specific protease otubain 1
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Interactome
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Publication Reference
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Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry.
Juris SJ, Shah K, Shokat K, Dixon JE, Vacratsis PO.
FEBS Letters 2006 Jan; 580(1):179.
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Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry.
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