ABCC11 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
ABCC11 polyclonal antibody (Cat # PAB11553) (0.5 ug/mL) staining of human breast lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ABCC11.
Immunogen
A synthetic peptide corresponding to human ABCC11.
Sequence
C-KVVEFDRPEVLRK
Host
Goat
Theoretical MW (kDa)
154,150
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ABCC11 polyclonal antibody (Cat # PAB11553) (0.5 ug/mL) staining of human breast lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ABCC11
Entrez GeneID
85320Protein Accession#
NP_115972.2;NP_660187.1Gene Name
ABCC11
Gene Alias
EWWD, MRP8, WW
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq
Other Designations
ATP-binding cassette protein C11|ATP-binding cassette transporter MRP8|ATP-binding cassette, sub-family C, member 11|OTTHUMP00000164191|multi-resistance protein 8
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Interactome
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Pathway
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Disease
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Publication Reference
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Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system.
Bortfeld M, Rius M, König J, Herold-Mende C, Nies AT, Keppler D.
Neuroscience 2006 Dec; 137(4):1247.
Application：IF, IHC-Fr, WB-Ti, WB-Tr, Dog, Human, Brain tumors, Glioma tissues, MDCK II cells.
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Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system.
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