KCNQ4 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
KCNQ4 polyclonal antibody (Cat # PAB11544) (2 ug/mL) staining of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of KCNQ4.
Immunogen
A synthetic peptide corresponding to human KCNQ4.
Sequence
C-DKGPSDAEVVDE
Host
Goat
Theoretical MW (kDa)
77.1, 71.2
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
KCNQ4 polyclonal antibody (Cat # PAB11544) (2 ug/mL) staining of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KCNQ4
Entrez GeneID
9132Protein Accession#
NP_004691.2;NP_751895.1Gene Name
KCNQ4
Gene Alias
DFNA2, KV7.4
Gene Description
potassium voltage-gated channel, KQT-like subfamily, member 4
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000009219|potassium channel KQT-like 4|potassium voltage-gated channel KQT-like protein 4
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Interactome
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Disease
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Publication Reference
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Differential distribution of stem cells in the auditory and vestibular organs of the inner ear.
Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Geleoc GS, Edge A, Holt JR, Heller S.
Journal of the Association for Research in Otolaryngology 2007 Mar; 8(1):18.
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Differential distribution of stem cells in the auditory and vestibular organs of the inner ear.
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