FMR1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of FMR1.
Immunogen
A synthetic peptide corresponding to human FMR1.
Sequence
C-RTGKDRNQKKEKPD
Host
Goat
Theoretical MW (kDa)
71.2
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
FMR1 polyclonal antibody (Cat # PAB11527) (0.1 ug/mL) staining of Kelly cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — FMR1
Entrez GeneID
2332Protein Accession#
NP_002015.1Gene Name
FMR1
Gene Alias
FMRP, FRAXA, MGC87458, POF, POF1
Gene Description
fragile X mental retardation 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). [provided by RefSeq
Other Designations
OTTHUMP00000024197|premature ovarian failure 1
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Interactome
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Disease
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Publication Reference
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The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome.
Hanson JE, Blank M, Valenzuela RA, Garner CC, Madison DV.
The Journal of Physiology 2007 Feb; 579(Pt 1):53.
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Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms.
Sittler A, Devys D, Weber C, Mandel JL.
Human Molecular Genetics 1996 Jan; 5(1):95.
Application:IF, WB-Ce, WB-Tr, Monkey, COS, Lymphoblasts, SH-SY5Y cells.
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The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome.
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