SH2D1B (phospho Y127) polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic phosphopeptide of SH2D1B.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y127 of human SH2D1B.
Sequence
C-NSNSDpYVDVLP
Host
Goat
Theoretical MW (kDa)
15.3
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SH2D1B
Entrez GeneID
117157Protein Accession#
NP_444512.2Gene Name
SH2D1B
Gene Alias
EAT2
Gene Description
SH2 domain containing 1B
Omim ID
608510Gene Ontology
HyperlinkGene Summary
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM
Other Designations
OTTHUMP00000029531|SH2 domain-containing molecule EAT2
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Interactome
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Pathway
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Publication Reference
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Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase.
Clarkson NG, Simmonds SJ, Puklavec MJ, Brown MH.
The Journal of Biological Chemistry 2007 Aug; 282(35):25385.
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Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase.
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